Beilstein J. Org. Chem.2013,9, 1432–1436, doi:10.3762/bjoc.9.161
the reaction were also revealed. This stereoselective radical reaction was used for synthesis of chiral pyroglutamic acid derivatives starting from a commercially available chiral amino acid.
Keywords: chelationcontrolledreaction; diastereoselective reaction; free radical; lactams; pyroglutamic
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Graphical Abstract
Scheme 1:
Radical addition to α-methylene-γ-phenyl-γ-butyrolactams.